Foxo3a-Mediated DNMT3B Impedes Cervical Cancer Cell Proliferation and Migration Capacities through Suppressing PTEN Promoter Methylation.

Hongying Li,Yuqin Yuan,Hong Dong,Tinghui Wang,Dunlan Zhang,Limin Zhou,Lu Chen, Xueyan He

Journal of investigative surgery : the official journal of the Academy of Surgical Research（2023）

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摘要

This research underlines that Foxo3a blocks its methylation with the PTEN promoter by inhibiting DNMT3B activity, which subsequently impedes cervical cancer cell progression.

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关键词

Cervical cancer,DNMT3B,Foxo3a,PTEN,promoter

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