Cannabidiol mediates epidermal terminal differentiation and redox homeostasis through aryl hydrocarbon receptor (AhR)-dependent signaling.

Young su Jang,Sugyeong Jeong,A-ram Kim,Bo Ram Mok,Su Ji son, Jae-snag Ryu, Woo Sung Son, Seok Kyun Yun,Seunghyun Kang,Hyun Jung Kim,Dong Hyun Kim,Jung U Shin

Journal of dermatological science（2023）

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摘要

Cannabidiol can be a modulator of the AhR-OVOL1-filaggrin axis and AhR-NRF2-NQO1 signaling, thus indicating a potential use of cannabidiol in skin barrier enhancement and reducing oxidative stress.

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关键词

AhR,Antioxidant,CBD,Epidermal equivalents,NHEKs,Skin barrier

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