Sema3G activates YAP and promotes VSMCs proliferation and migration via Nrp2/PlexinA1

Xue-Yang Luo, Xiao Fu,Fang Liu,Jiang-Yun Luo,Alex F. Chen

Cellular Signalling（2023）

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摘要

Our results indicated that ECs-derived Sema3G under diabetic condition activated YAP and promoted HASMCs proliferation and migration via Nrp2/PlexinA1. Thus, inhibition of Sema3G may hold therapeutic potential against diabetes-associated intimal hyperplasia.

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关键词

Vascular smooth muscle cells,Semaphorin 3G,Neuropilin-2,PlexinA1,Proliferation,Diabetes

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