Towards a Fully Implantable Closed-Loop Opto-Electro Stimulation Interface for Motor Neuron Disease Treatment.

This paper presents a fully-implantable closed-loop opto-electro stimulation interface for motor neuron disease studies, designed for experiments with freely moving rodents. A low power consumption Bluetooth data link is used to wirelessly control 64 opto-electro stimulation channels and receive neural recording data. The implant is powered by a wirelessly rechargeable lithium-ion battery, which can support 2.5 hours continuous operation with a stimulation output up to 10 mA. The battery is recharged using a QI standard wireless inductive power link, which can deliver >100 mW power at a distance of 2 cm. The total size of the implant system is 29 mm x 20 mm x 13 mm. Its performance is compared with the state-of-the-art.