DC-SIGN (CD209) Promoter -336 A/G Polymorphism is Not Associated with Dengue Fever at Burkina Faso, West Africa

Objective: The aim of this study was to characterize the polymorphisms of the DC-SIGN (-336 A/G, rs4804803) gene and their association with the immunopathogenicity of dengue fever in Burkina Faso.Methods: A total of three hundred forty-one subjects, patients of all ages have been included in the study: 208 persons presenting clinical signs of dengue fever which were confirmed by diagnostic and 133 Healthy Controls.Genotyping for the CD209 variant (-336 A/G, rs4804803) was carried out using TaqMan SNP Genotyping Assays.Haplotype frequencies were inferred and compared between the study groups.Results: The percentage of men was 61.88% (211/341) and 38.12% (130/341) for women.The highest frequency of dengue fever (77.42%) was noted in patients with age between 20 to 40 years.Around 1.52% of the study population was positive for HIV, 40.55% were carriers of HBV and 3.83% of HCV.Genotype distribution of the CD209 variant (-336 A/G, rs4804803) was in Hardy-Weinberg equilibrium in both patients and controls.The frequency of allele A was higher than allele G; however, statistical analyses showed that there is no significant difference in genotypes GG, AG and AA in patients and controls.Conclusion: This related no significant association with dengue for the variant of -336 A/G in the DC-SIGN gene in an Ouagadougou population.However, our results offered the SNP frequencies in a West African population, which might be useful for the study of ethnic groups.