Acute sleep loss decreases CSF-to-blood clearance of Alzheimer's disease biomarkers.

Haiyan Liu,Nicolas R Barthélemy,Vitaliy Ovod,James G Bollinger,Yingxin He,Samir L Chahin, Brendan Androff,Randall J Bateman,Brendan P Lucey

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

These findings show that sleep loss alters some plasma AD biomarkers by lowering brain clearance mechanisms and needs to be taken into account when interpreting individual plasma AD biomarkers but not ratios.

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关键词

Alzheimer's disease,biomarkers,sleep

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