Partially replacing cyclophosphamide with bendamustine in combination with cyclosporine A improves survival and reduces xenogeneic graft-versus-host-disease.

Kristy E Gilman,Megan J Cracchiolo,Andrew P Matiatos,Dan W Davini,Richard J Simpson,Emmanuel Katsanis

Frontiers in immunology（2022）

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摘要

Together, we illustrate that the use of CY/BEN is safe and shows similar control of xGvHD to CY/CY, but when combined with CSA, survival with CY/BEN is significantly prolonged compared to CY/CY.

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关键词

allogeneic hematopoietic cell transplantation,bendamustine,cyclophosphamide,graft-versus-host disease,xenogeneic

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