Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study.

Taro Nakazawa,Tomoyuki Ohara,Naoki Hirabayashi,Yoshihiko Furuta,Jun Hata,Mao Shibata,Takanori Honda,Takanari Kitazono,Tomohiro Nakao,Toshiharu Ninomiya

Psychiatry and clinical neurosciences（2023）

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摘要

The risk of dementia increased significantly with higher WMLV/ICV levels. An additive increment in dementia risk was observed with higher WMLV/ICV levels and lower TBV/ICV levels or a higher number of dementia-related brain regional atrophy, suggesting the importance of prevention or control of cardiovascular risk factors.

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关键词

Alzheimer disease,Vascular,cerebral small vessel diseases,dementia,leukoencephalopathies

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