Characterizing T cell responses to enzymatically modified beta cell neo-epitopes.

Hai Nguyen,David Arribas-Layton,I-Ting Chow,Cate Speake,William W Kwok,Martin J Hessner,Carla J Greenbaum,Eddie A James

Frontiers in immunology（2022）

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摘要

These results reinforce the relevance of PTM neo-epitopes in human disease and suggest that distinct responses to neo-antigens promote a more rapid decline in beta cell function.

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关键词

T cell,Type 1 diabetes (T1D),at risk,citrullinated autoantigens,deamidated autoantigens

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