Exosomes of adipose-tissue-derived stem cells over-expressing Neat1 promote wound healing by sponging miR-17-5p and inducing autophagy protein Ulk1.

Yang An,Fei Huang,Xiaojie Tan,Shiou Zhu,Yonghuan Zhen,Yujia Shang,Pengbing Ding,Dong Li,Junhao Wu

Plastic and reconstructive surgery（2022）

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摘要

Collectively, these results reveal a novel molecular mechanism that the autophagy pathway enhanced by Neat1/miR-17-5p/Ulk1 axis can promote the wound-healing and suggest that lncRNA Neat1 loaded by ADSCs-exo might be a potential therapeutic target for skin no-healing wounds.

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关键词

neat1 promote wound healing,stem cells,wound healing,autophagy protein,adipose-tissue-derived,over-expressing

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