Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus

Jian Zhang,Yuan Zhao,Yidan Zhang,Ya Gao,Shuyue Li,Cui Chang,Xuan Gao,Jingru Zhao,Guofeng Yang

Neuroscience Letters（2023）

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摘要

•ALA improves cognitive function in ageing mice.•TMT based LC-MS/MS is exacuted to identify the protein change of ALA in brain ageing.•ALA upregulates the terminal bouton and lipid transporter activity in ageing mice.•ALA downregulates apoptosis, and neuroinflammatory associated proteins in ageing mice.

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关键词

Alpha lipoic acid,Brain ageing,Proteomics,Tandem mass tags

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