Patient-specific voxel-level dose prescription for prostate cancer radiotherapy considering tumor cell density and grade distribution.

Yutong Zhao,Annette Haworth,Hayley M Reynolds,Emily J Her,Yu Sun,Robert Finnegan,Pejman Rowshanfarzad,Martin A Ebert

Medical physics（2023）

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摘要

Biologically-optimized redistribution of a boost dose can yield TCP improvement relative to a uniform-boost dose distribution. Patient-specific tumor characteristics can be used to predict the likelihood of benefit from a redistribution approach for the individual patient.

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关键词

TCP model,dose redistribution,prostate cancer radiotherapy

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