Impact of genetic variants involved in the lipid metabolism pathway on progression free survival in patients receiving bevacizumab-based chemotherapy in metastatic colorectal cancer: a retrospective analysis of FIRE-3 and MAVERICC trials.

Jingyuan Wang,Joshua Millstein,Yan Yang,Sebastian Stintzing,Hiroyuki Arai,Francesca Battaglin,Natsuko Kawanishi,Shivani Soni,Wu Zhang,Christoph Mancao,Chiara Cremolini,Tianshu Liu,Volker Heinemann,Alfredo Falcone,Lin Shen,Heinz-Josef Lenz

EClinicalMedicine（2023）

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摘要

This work was supported by the National Cancer Institute [P30CA 014089 to H.-J.L.], Gloria Borges WunderGlo Foundation, Dhont Family Foundation, Victoria and Philip Wilson Research Fund, San Pedro Peninsula Cancer Guild, Ming Hsieh Research Fund, Eddie Mahoney Memorial Research Fund, Shanghai Sailing Program (22YF1407000), China National Postdoctoral Program for Innovative Talents (BX20220084), China Postdoctoral Science Foundation (2022M710768), National Natural Science Foundation of China (82202892).

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关键词

3' UTR, 3′ untranslated regions,ACACA, acetyl-coA carboxylase,ADD, antiangiogenic drug,AIM, ancestry informative markers,Bevacizumab,Biomarker,CEU, Utah residents with Northern and Western European ancestry from the CEPH collection,CORECT, Colorectal Cancer Transdisciplinary,CPT1A, carnitine palmitoyl transferase 1A,CRC, colorectal cancer,Colorectal cancer,ECOG PS, Eastern Cooperative Oncology Group performance status,FAO, fatty acids β-oxidation,FASN, fatty acid synthase,LPCAT1, lysolecithin acyltransferase 1,LPCAT2, lysolecithin acyltransferase 2,Lipid metabolism,MAF, minor allele frequency,MUFA, monounsaturated fatty acids,ORR, overall response rate,OS, overall survival,PFS, progression-free survival,SNP, single nucleotide polymorphisms,mCRC, metastatic colorectal cancer

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