Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease.

Dan Wang, Ling Yin,Rongyu Chen,Wanlin Tan,Luqun Liang,Jiayi Xiang,Huifang Zhang,Xingcheng Zhou,Huaqing Deng,Bing Guo,Yuanyuan Wang

Frontiers in medicine（2022）

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摘要

In conclusion, HG induces renal tubular epithelial cell senescence, and the secretion of senescence-associated proteins and Shh mediates inflammatory responses and fibroblast activation and proliferation, ultimately leading to renal fibrosis.

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关键词

SASP,Shh,diabetic kidney disease,inflammation,renal tubular epithelial cells,senescence

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