Dissecting the role of cancer-associated fibroblast-derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single-cell transcriptomic study.

Shaoquan Zheng,Jie-Ying Liang,Yuhui Tang,Jindong Xie,Yutian Zou,Anli Yang,Nan Shao,Xiaying Kuang,Fei Ji,Xuefeng Liu,Wenwen Tian,Weikai Xiao,Ying Lin

Clinical and translational medicine（2023）

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摘要

We highlighted the importance of CAFs in the tumor microenvironment and revealed that the BGN, which is mainly derived from CAFs, may be applicable in clinical practice and serve as a therapeutic target in immunotherapy resistance.

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关键词

tumor microenvironment ,cancer-associated fibroblasts,immunotherapy,tumor biomarker

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