Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization.

Marta Vila-Pueyo,Ester Cuenca-León,Ana C Queirós,Marta Kulis,Cèlia Sintas,Bru Cormand,José Ignacio Martín-Subero,Patricia Pozo-Rosich,Noèlia Fernàndez-Castillo,Alfons Macaya

Cephalalgia : an international journal of headache（2023）

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摘要

Our results may provide insights into the underlying physiological mechanisms of migraine with aura and emphasize the role of epigenetics in migraine susceptibility.

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关键词

Cortical spreading depolarization (CSD),DNA methylation,animal models,epigenetics,migraine,migraine aura,prophylactic treatment,topiramate,valproate

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