Gut Microbiota-Derived Glutamine Attenuates Liver Ischemia/Reperfusion Injury via Macrophage Metabolic Reprogramming.

Tianfei Lu,Qing Li,Weiwei Lin, Xianzhe Zhao,Fu Li,Jianmei Ji,Yu Zhang,Ning Xu

Cellular and molecular gastroenterology and hepatology（2023）

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摘要

These findings show that the gut microbiota and its metabolites play critical roles in hepatic I/R injury by modulating macrophage metabolic reprogramming. Potential therapies that target macrophage metabolism, including antibiotic therapies and novel immunometabolism modulators, can be exploited for the treatment of liver I/R injury.

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关键词

Glutamine,Immunometabolism,Liver Ischemia/Reperfusion Injury,Macrophage Reprogramming,Microbiota,a-ketoglutarate

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