Clinical application of platelet-rich fibrin to enhance dental implant stability: A systematic review and meta-analysis

Objective: To investigate the effect of platelet-rich fibrin application on implant stability. Study design: Five databases, namely, PubMed, Embase, Web of Science, Wiley, and China Na-tional Knowledge Infrastructure, were searched for reports published up to November 20, 2022. Randomized controlled trials (RCT), including parallel RCTs and split-mouth RCTs, with at least 10 patients/sites were considered for inclusion. Results: After screening based on the inclusion criteria, ten RCTs were included. Low heteroge-neity was observed in study characteristics, outcome variables, and estimation scales (I2 = 27.2%, P = 0.19). The qualitative and meta-analysis results showed that PRF increased the effect of implant stabilizers after implant surgery. Conclusions: The results of the present systematic review and meta-analysis suggest that PRF can increase implant stability after implant surgery. PRF may also have a role in accelerating bone healing and tends to promote new bone formation at the implant site.