Three new chromones from the whole plants of Chamaecrista rotundifolia and their anti-rotavirus activities

() is a perennial herb of leguminosae, which increasingly being grown as a forage in China. In our search for original bioactive metabolites from plants, the phytochemical reinvestigation of the was carried out, which led to the isolation of three new (-) and six known (-) chromones. Their structures were confirmed by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds - were evaluated for their anti-rotavirus activities, and the results revealed that compounds - exhibited potential anti-rotavirus activities with therapeutic index (TI) valves in the range of 12.0 ∼ 20.2, respectively.