Tandem Denitrogenation Oxidative Coupling Reaction of Phenyl Vinyl Azides and Cyclic Ethers Under Metal-Free Conditions

An efficient synthesis of alpha-oxoalkyl ketones is described. The current method is the coupling reaction of phenyl vinyl azides and cyclic ethers under metal-free conditions. The reaction is conducted with KI as the additive and TBHP (70 % solution in water) as the oxidant at 60 degrees C for 12 h. A wide range of alpha-oxyalkylated ketones with broad functionalities has been synthesized in moderate to good yields.