Analysis of the TSER and G>C variants in the TYMS gene: a high frequency of low expression genotypes predicted in the Mexican population.

Alma Faviola Favela-Mendoza, Andrea Dinorah Godínez-López,Mariana Chávez-Arreguin,José Alonso Aguilar-Velázquez,Gabriela Martínez-Cortes,Héctor Rangel-Villalobos

Annals of human biology（2023）

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摘要

The high frequency of genotypes associated with low TS enzyme expression justifies obtaining the gene variant profile in Mexican patient's candidates to pharmaceutical treatments like 5'-Fluoracil, methotrexate, and pemetrex.

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关键词

5′-fluoracil,Mexico,TSER,Thymidylate synthase,rs2853542

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