Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling.

Dandan Li,Anne M Miermont,Rushikesh Sable,Humair S Quadri,Lesley A Mathews Griner,Scott E Martin,Taivan Odzorig,Soumita De,Marc Ferrer,Astin S Powers,Stephen M Hewitt,Udo Rudloff

Molecular cancer research : MCR（2023）

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摘要

The CNKSR1 scaffold, identified within an RNAi screen as a novel mediator of resistance to MEK inhibition in pancreas cancer, connects the MAPK pathway and AKT signaling and may be adopted as a biomarker to select patients for combined MEK AKT blockade.

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关键词

pancreas cancer,kinase suppressor,mapk inhibition responsiveness,akt signaling

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