Suppression of GCH1 Sensitizes Ovarian Cancer and Breast Cancer to PARP Inhibitor.

Siyuan Wang,Yu Xia, Pu Huang, Cheng Xu, Yiyu Qian,Tian Fang,Qinglei Gao

Journal of oncology（2023）

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摘要

Our results illustrated that PARP inhibitors promote GCH1 expression via the JAK-STAT pathway. We also elucidated the potential relationship between GCH1 and the homologous recombination repair pathway and proposed a combination regimen of GCH1 suppression with PARP inhibitors in breast and ovarian cancers.

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