Torin1 restores proliferation rate in Charcot-Marie-Tooth disease type 2A cells harbouring MFN2 (mitofusin 2) mutation.

Paola Zanfardino,Alessandro Amati,Easter Anna Petracca,Filippo M Santorelli,Vittoria Petruzzella

Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology（2022）

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摘要

Overall, our study provides evidence for mTORC2, as a novel molecular target that lies upstream of AKT to restore the cell proliferation rate in CMT2A fibroblasts.

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关键词

AKT,Charcot-Marie-Tooth type 2A2,cell proliferation,mTORC2,mitofusin2

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