DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.

Kazufumi Kunimura,Sayaka Akiyoshi,Takehito Uruno,Keisuke Matsubara,Daiji Sakata, Kenji Morino, Kenichiro Hirotani,Yoshinori Fukui

The Journal of allergy and clinical immunology（2023）

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摘要

DOCK2 regulates MRGPRX2/B2-mediated MC degranulation through Rac activation and PAK1 phosphorylation, thereby indicating that the DOCK2-Rac-PAK1 axis could be a target for preventing drug-induced anaphylaxis.

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关键词

DOCK2,Drug-induced anaphylaxis,MRGPRB2,MRGPRX2,PAK1,Rac,mast cell,phosphorylation,secretory granules

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