CNS Downstaging: An Emerging Treatment Paradigm for Extensive Brain Metastases in Oncogene-Addicted Lung Cancer.

Jacob Langston,Tejas Patil,D Ross Camidge,Paul A Bunn,Erin L Schenk,Jose M Pacheco,James Jurica,Timothy V Waxweiler,Brian D Kavanagh,Chad G Rusthoven

Lung cancer (Amsterdam, Netherlands)（2023）

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摘要

In this initial case series, we describe CNS downstaging as a promising multidisciplinary treatment paradigm involving the upfront administration CNS-active systemic therapy and close MRI surveillance for extensive BrMs as a strategy to avoid upfront WBRT and to convert some patients into SRS candidates.

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关键词

Anaplastic lymphoma kinase (ALK),Brain metastases,Epidermal growth factor receptor (EGFR),Non-small cell lung cancer (NSCLC),ROS1,Stereotactic radiosurgery (SRS),Tyrosine kinase inhibitor (TKI),Whole brain radiotherapy (WBRT)

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