Risk factors and drugs that trigger the onset of Stevens-Johnson syndrome and toxic epidermal necrolysis: A population-based cohort study using the Shizuoka Kokuho database.

Nanako Ubukata,Eiji Nakatani,Hideo Hashizume,Hatoko Sasaki,Yoshiki Miyachi

JAAD international（2023）

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摘要

In this cohort population from a database representing the general population, the risks of developing SJS/TEN were old age and a history of type 2 diabetes, peripheral vascular disease, and systemic autoimmune disease. Furthermore, in addition to previously reported drugs, the administration of immune checkpoint inhibitors, insulin, and type 2 diabetes agents, may trigger the development of SJS/TEN.

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关键词

CI, confidential interval,HR, hazard ratio,ICD-10, International Classification of Disease, 10th revision,SJS, Stevens–Johnson syndrome,SKDB, Shizuoka Kokuho Database,Stevens–Johnson syndrome,TEN, toxic epidermal necrolysis,claims database,drug eruption,pharmacoepidemiology,population-based cohort study,risk factor,safety,toxic epidermal necrolysis

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