CTTN Overexpression Confers Cancer Stem Cell-like Properties and Trastuzumab Resistance via DKK-1/WNT Signaling in HER2 Positive Breast Cancer.

So-Jeong Moon,Hyung-Jun Choi, Young-Hyeon Kye,Ga-Young Jeong,Hyung-Yong Kim,Jae-Kyung Myung,Gu Kong

Cancers（2023）

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摘要

CTTN activates DKK-1/Wnt/β-catenin signaling to induce trastuzumab resistance. We propose that CTTN is a novel biomarker indicating a poor prognosis and a possible therapeutic target for overcoming trastuzumab resistance.

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CTTN,HER2 positive breast cancer,cancer stem cells,trastuzumab resistance

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