Association of GBA genotype with motor and cognitive decline in Chinese Parkinson's disease patients.

Jingru Ren,Gaiyan Zhou,Yajie Wang,Ronggui Zhang,Zhiying Guo, Hao Zhou,Huifen Zheng,Yu Sun,Changyan Ma,Ming Lu,Weiguo Liu

Frontiers in aging neuroscience（2023）

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摘要

-PD is associated with faster motor and cognitive decline, specifically greater disability in terms of bradykinesia, axial impairment, and visuospatial/executive function. Better understanding of -PD progression may help predict prognosis and improve clinical trial design.

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关键词

GBA,Parkinson’s disease,cognitive decline,longitudinal,motor impairment

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