Addition of a Genetic Risk Score for Identification of Men with a Low Prostate-specific Antigen Level in Midlife at Risk of Developing Lethal Prostate Cancer.

Chaoran Ma,Caroline Ericsson,Sigrid V Carlsson,Hans Lilja,Adam Kibel,Rebecca E Graff,Anna Plym,Edward Giovannucci,Lorelei A Mucci,Mark A Preston,Kathryn L Penney

European urology open science（2023）

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摘要

A subset of men develop fatal prostate cancer despite having low prostate-specific antigen (PSA) levels in middle age. A risk score based on multiple genes can help in predicting men who may be at risk of developing lethal prostate cancer and who should be advised to have regular PSA measurements.

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关键词

Lethal prostate cancer,Polygenic risk score,Prostate-specific antigen

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