Identification of biomarkers that predict renal flare in childhood-onset lupus nephritis with mycophenolate acid

Ziwei Li,Jinglin Wang,Yidie Huang,Qian Shen,Li Sun,Hong Xu,Zhiping Li

International Immunopharmacology（2023）

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摘要

•First study of pediatric lupus nephritis to identify risk predictors of renal flare.•Cox regression combined with population pharmacokinetic model.•IgG as a predictor of mycophenolic acid clearance.•Mycophenolic acid exposure and IgG were good predictors of renal flare.

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关键词

Mycophenolic acid,Childhood-onset lupus nephritis,Immunoglobulin G,Renal flare,Risk factors

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