Nicotinamide Phosphoribosyltransferase-elevated NAD + biosynthesis prevents muscle disuse atrophy by reversing mitochondrial dysfunction.

Yao Zhang,Yingming Wang,Shuai Lu,Rui Zhong,Zhilin Liu,Qichun Zhao,Chongyang Wang

Journal of cachexia, sarcopenia and muscle（2023）

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摘要

NAMPT-elevated NAD biosynthesis can prevent disuse atrophy of skeletal muscles that predominantly composed with either slow-twitch (type I) or fast-twitch (type II) fibres by reversing mitochondrial dysfunction.

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关键词

Fatty infiltration,Mitochondrial dysfunction,Muscle disuse atrophy,NAMPT,Rotator cuff tear

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