The immunoregulatory effect of the TREM2-agonist Sulfavant A in human allogeneic mixed lymphocyte reaction.

Giusi Barra,Carmela Gallo,Dalila Carbone,Marcello Ziaco,Mario Dell'Isola,Mario Affuso,Emiliano Manzo,Genoveffa Nuzzo,Laura Fioretto,Giuliana D'Ippolito,Raffaele De Palma,Angelo Fontana

Frontiers in immunology（2023）

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摘要

These results prove that SULF A can modulate DC-T cell synapse and stimulate lymphocyte proliferation and activation. In the hyperresponsive and uncontrolled context of the allogeneic MLR, the effect is associated to differentiation of regulatory T cell subsets and dampening of inflammatory signals.

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cancer immunotherapy,dendritic cells,drug discovery,homeostasis,immunoregulation,inflammation,small molecule,vaccine adjuvant

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