An umpolung strategy for chemically selective intermolecular cross-enolate-type coupling of N -alkenoxypyridinium salts with aldehydes.

Chemical communications (Cambridge, England)(2023)

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An efficient method for the synthesis of 1,4-ketoaldehydes the cross-coupling of -alkenoxyheteroarenium salts and primary aldehydes is developed. This method provides a broad substrate scope and excellent functional group compatibility. The utility of this method is demonstrated the diverse transformations of heterocyclic compounds and cycloheptanone, as well as the late-stage functionalization of biorelevant molecules.
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