Tissue Inhibitor Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Kinetics Following Exposure to High-Dose Methotrexate

Jason N. Barreto,Erin F. Barreto,Kristin C. Mara,Andrew D. Rule,John C. Lieske,Callen D. Giesen,Carrie A. Thompson,Nelson Leung,Thomas E. Witzig,Kianoush B. Kashani

Kidney360（2023）

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摘要

Key Points Urinary TIMP2×IGFBP7 (uTIMP2×IGFBP7) concentrations experienced a rapid and sustained decline after high-dose methotrexate (MTX) exposure. uTIMP2×IGFBP7 kinetics and concentrations after high-dose MTX exposure demonstrated no utility in predicting AKI.

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关键词

inhibitor,insulin-like,high-dose

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