4-oxoquinoline-3-carboxamide acyclonucleoside phosphonates hybrids: Human MCF-7 breast cancer cell death induction by oxidative stress-promoting and in silico ADMET studies

Thayná R. Machado,Letícia V. Faro,Angélica L.do Nascimento Mello,David de O. Silva,Bárbara de A. Abrahim-Vieira,Carlos R. Rodrigues, Rita Hemanuelle S. Silva, Claudio S.Viana Junior,Mauro Sola-Penna,Fernanda da C.S. Boechat,Marcos C. de Souza,Patricia Zancan,Maria Cecília B.V. de Souza,Alessandra M.T. de Souza

Journal of Molecular Structure（2023）

引用 3|浏览7

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摘要

•Compounds 15a-k were synthesized as antitumoral agents.•15c, 15e, 15g, and 15k showed significant cytotoxicity.•15c, g, and k increased the levels of reactive species and superoxide ions.•In silico toxicity screening showed that 15g presented low hepatotoxicity risk.•15g is a potential candidate to optimize for the development of anticancer agents.

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关键词

4-oxoquinoline,Acyclonucleoside phosphonate,Breast cancer,Antitumor agents,In silico toxicology

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