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Genetic propensity for cerebral amyloidosis and risk of mild cognitive impairment and Alzheimer's disease within a cognitive reserve framework.

Niki Mourtzi,Sokratis Charisis,Angeliki Tsapanou,Eva Ntanasi,Alexandros Hatzimanolis,Alfredo Ramirez,Stefanie Heilmann-Heimbach,Benjamin Grenier-Boley,Jean-Charles Lambert,Mary Yannakoulia,Mary Kosmidis,Efthimios Dardiotis,Georgiios Hadjigeorgiou,Paraskevi Sakka,Marios Georgakis,Stern Yaakov,Nikolaos Scarmeas

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要
A super-additive effect of PRSAβ42 and CR on AD/aMCI risk was observed. CR influence was evident in participants with high PRSAβ42.
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关键词
Alzheimer's disease,cognitive decline,cognitive reserve,polygenic risk score
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