A multi-task SCCA method for brain imaging genetics and its application in neurodegenerative diseases.

Xin Zhang,Yipeng Hao,Jin Zhang, Yanuo Ji,Shihong Zou,Shijie Zhao,Songyun Xie,Lei Du

Computer methods and programs in biomedicine（2023）

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摘要

These results on simulated data, ADNI and PPMI cohorts suggested the effectiveness and generalizability of our method in identifying meaningful disease-related markers. DDG-MTSCCA could be a powerful tool in brain imaging genetics, worthy of in-depth study.

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关键词

Brain imaging genetics,Feature selection,Multi-task sparse canonical correlation analysis (MTSCCA),Parameter decomposition

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