H2O2 activation over Cu-Schiff bases nanozyme for the removal of amlodipine: Kinetics, mechanism and toxicity evaluation

Zhimin Gong,Jiahao Wang,Shuai Shao,Bo Fan,Yanqi Shi,Li Qian,Kun Lu,Shixiang Gao

Separation and Purification Technology（2023）

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摘要

•A kind of Cu@SB nanozyme with peroxidase-like activities was constructed.•Cu@SB nanozyme effectively activate H2O2 to degrade AML.•1O2 and ∙OH were responsible for the degradation of AML.•Degradation pathway of AML was proposed based on DFT calculations and LC-MS2 analysis.•ECOSAR analysis showed the toxicities of most intermediates were lower than AML.

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关键词

Cu-Schiff base,Artificial nanozyme,Amlodipine,Kinetics,Degradation pathway,Activation mechanism

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