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Disruption of Enterohepatic Circulation of Bile Acids Ameliorates Small Bowel Resection Associated Hepatic Injury

Maria E. Tecos,Allie E. Steinberger, Jun Guo,Deborah C. Rubin,Nicholas O. Davidson,Brad W. Warner

Journal of Pediatric Surgery（2023）

Cited 2|Views17
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Abstract
•DDistal SBR and TUDCA supplementation decreases oxidative stress and SBR-associated hepatic injury.•Distal SBR and TUDCA supplementation have healthier bile acid profiles compared to proximal SBR.•Enterohepatic circulation has critical involvement in liver injury prevention, but distal SBR and TUDCA supplementation likely differ in the mechanism utilized to confer hepatoprotection.
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Key words
Short bowel syndrome,Small bowel resection,Enterohepatic circulation,Hepatic injury,Bile acids
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