Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-Ⅱ and its Mechanism of signal transmission in vitro

Dear Editor, COVID-19 cases showed a significant decrease in the number of peripheral CD4+and CD8+T cells accompanied by over-activation of cells.1 HHV8-derived viral macrophage inflammatory protein vMIP-Ⅱ is the only broad-spectrum chemokine receptor inhibitor that binds to three subtribes of chemokine receptors,which can significantly increase the specific cell immune response in infected organisms and have an effect of reducing plasma viral load on the viremia period.2-4 Here we report the effect of vMIP-Ⅱ in COVID-19.