Kaempferol with Verapamil impeded panoramic chemoevasion pathways in breast cancer through ROS overproduction and disruption of lysosomal biogenesis.

Sourav Kumar Nandi,Niloy Chatterjee,Tanaya Roychowdhury,Ayan Pradhan, Sumaiya Moiz,Krishnendu Manna,Diptendra Kumar Sarkar,Pubali Dhar,Amitava Dutta,Soma Mukhopadhyay,Rittwika Bhattacharya

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

Our ex-vivo and in-silico studies revealed that our candidate drug combination KV, could effectively target several pathways regulating chemoresistance, that were not hitherto studied in the same experimental setup and thus may be endorsed for therapeutic purposes.

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关键词

Anti-cancerous,Chemoresistance,Low glucose,Reactive oxygen species,Stem cells,Synergism

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