Corrigendum to Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants Randomized. Am J Geriatr Psychiatry 2019;27(10):1138–1152. doi: 10.1016/j.jagp.2019.04.005

In the paper titled, “Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants Randomized,” published by Cristancho and co-authors in October 2019,1Cristancho P Lenard E Lenze EJ et al.Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM): study design and treatment characteristics of the first 396 participants randomized.Am J Geriatr Psychiatr. 2019; 27: 1138-1152https://doi.org/10.1016/j.jagp.2019.04.005Abstract Full Text Full Text PDF PubMed Scopus (34) Google Scholar there were errors in the text. In short, the paper described details about the methodology of the clinical trial, Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM). The paper stated in several places that there were several primary effectiveness outcomes of OPTIMUM. For example, in the abstract, the paper stated, “Primary outcomes include: 1) symptom remission (Montgomery Asberg Depression scale ≤10); 2) psychological well-being, comprising positive affect, general life satisfaction, and purpose…” The statistical analysis plan of OPTIMUM has only one primary outcome. This is Psychological Well-being, which combines two subscales of positive affect and general life satisfaction from the NIH Toolbox. OPTIMUM's statistical analysis plan does not have a plan to correct for multiple effectiveness outcomes. Remission from depression, although an important outcome to clinicians, was a secondary outcome. The OPTIMUM trial is now complete and findings have been published elsewhere.2Lenze EJ, Mulsant BH, Roose SP, et al. Trial of antidepressant augmentation vs. switching in treatment-resistant geriatric depression. N Engl J Med 2023. doi:10.1056/NEJMoa2204462. Online ahead of print.Google Scholar Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants RandomizedThe American Journal of Geriatric PsychiatryVol. 27Issue 10PreviewA challenge in the care of older adults with major depressive disorder is failure to respond to first-line pharmacotherapy: one-half to two-thirds of these older adults fail to remit with a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI).1 Late-life treatment-resistant depression (LLTRD) worsens medical outcomes,2 increases disability,3 hastens cognitive decline, and increases risk of dementia.4 The societal toll of unremitted depression is high: it is strongly associated with suicide,2 it carries the highest loss of quality of life, and has the highest mortality among chronic conditions. Full-Text PDF