Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar Carcinoma.

Adam B Francisco,Jine Li,Alaa R Farghli,Matt Kanke,Bo Shui,Paul R Munn,Jennifer K Grenier,Paul D Soloway,Zhangjie Wang,Lola M Reid,Jian Liu,Praveen Sethupathy

Cancer research communications（2022）

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摘要

This study leverages a multi-disciplinary approach, including state-of-the-art chemical analyses and cutting-edge single-cell genomic technologies, to identify for the first time a marked chondroitin sulfate aberrancy in FLC that could open novel therapeutic avenues in the future.

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