Effect of Food on the Pharmacokinetics and Safety of a Novel c-Met Inhibitor SCC244: A Randomized Phase I Study in Healthy Subjects.

Juan Wu,Hongrong Xu,Hui Li,Lei Ma,Juan Chen,Fei Yuan,Lei Sheng,Chao Liu,Weili Chen,Xuening Li

Drug design, development and therapy（2023）

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摘要

The bioavailability of the tablet formulation of SCC244 was significantly increased when administered with high- and low-fat meals. However, the meals did not affect the median T and t. Safety under different fed conditions was comparable to fasted conditions in this study.

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关键词

SCC244,c-Met inhibitor,food effect,pharmacokinetics,safety

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