Determination of Azaspiracids in Edible Shellfish by a Modified QuEChERS Method Coupled with Ultra High Performance Liquid Chromatography Triple Quadrupole Mass Spectrometry

A method has been developed for the detection of azaspiracids in shellfish. This method uses modified QuEChERS for sample preparation. The separation and quantitation was accomplished with an Agilent 1290 Infinity LC system coupled with an Agilent 6460 Triple Quadrupole LC/MS. The study outlined in this application note demonstrates that the method is easy to operate, rapid, and reliable, providing separation and detection at levels that are well below those defined by regulation. *Chin. J. Chromatogr., 2013, 31(10), 939-945.