Intratracheally injected human-induced pluripotent stem cell-derived pneumocytes and endothelial cells engraft in the distal lung and ameliorate emphysema in a rat model.
The Journal of thoracic and cardiovascular surgery（2023）
摘要
Our findings suggest that human induced pluripotent stem cell-derived distal lung cells can engraft in emphysematous lungs and participate in the formation of functional distal lung units to ameliorate the progression of emphysema.
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关键词
cell therapy,distal lung tissue regeneration,emphysema,endothelial cells,induced pluripotent stem cells,pneumocytes
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