Don't Break the Axis: Placental Inflammation Leads to Congenital Heart Disease.

HomeCirculationVol. 147, No. 12Don’t Break the Axis: Placental Inflammation Leads to Congenital Heart Disease No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextDon’t Break the Axis: Placental Inflammation Leads to Congenital Heart Disease José Luis de la Pompa José Luis de la PompaJosé Luis de la Pompa Correspondence to: José Luis de la Pompa, PhD, Intercellular Signaling in Cardiovascular Development & Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain. Email E-mail Address: [email protected] https://orcid.org/0000-0001-6761-7265 Intercellular Signaling in Cardiovascular Development & Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain. Ciber de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, Madrid, Spain. Search for more papers by this author Originally published21 Mar 2023https://doi.org/10.1161/CIRCULATIONAHA.123.063657Circulation. 2023;147:973–976This article is a commentary on the followingPlacental Inflammation Leads to Abnormal Embryonic Heart DevelopmentFootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Sources of Funding and Disclosures, see page 976.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: José Luis de la Pompa, PhD, Intercellular Signaling in Cardiovascular Development & Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029 Madrid, Spain. Email [email protected]esReferences1. Brosens I, Robertson WB, Dixon HG. 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There is a strong association between early preeclampsia and congenital heart defects: a large population-based, retrospective study.Gynecol Obstet Invest. 2021; 86:40–47. doi: 10.1159/000506804CrossrefMedlineGoogle Scholar13. Nadkarni S, Smith J, Sferruzzi-Perri AN, Ledwozyw A, Kishore M, Haas R, Mauro C, Williams DJ, Farsky SH, Marelli-Berg FM, et al. Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy.Proc Natl Acad Sci USA. 2016; 113:E8415–E8424. doi: 10.1073/pnas.1611944114CrossrefMedlineGoogle Scholar14. Malak TM, Ockleford CD, Bell SC, Dalgleish R, Bright N, Macvicar J. Confocal immunofluorescence localization of collagen types I, III, IV, V and VI and their ultrastructural organization in term human fetal membranes.Placenta. 1993; 14:385–406. doi: 10.1016/s0143-4004(05)80460-6CrossrefMedlineGoogle Scholar15. Black KD, Horowitz JA. Inflammatory markers and preeclampsia: a systematic review.Nurs Res. 2018; 67:242–251. doi: 10.1097/NNR.0000000000000285CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesPlacental Inflammation Leads to Abnormal Embryonic Heart DevelopmentEleanor J. Ward, et al. Circulation. 2023;147:956-972 March 21, 2023Vol 147, Issue 12 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.063657PMID: 36944033 Originally publishedMarch 21, 2023 KeywordsplacentaEditorialscongenitalheart defectsinflammationPDF download Advertisement SubjectsAngiogenesisAnimal Models of Human DiseaseBasic Science ResearchDevelopmental Biology