Joint Effects Between CDKN2B/P15 Methylation and Environmental Factors on the Susceptibility to Gastric Cancer

The incidence of gastric cancer has long been at a high level in China, seriously affecting the health of Chinese people. This case‒control study was performed to identify gene methylation biomarkers of gastric cancer susceptibility. A total of 393 gastric cancer cases and 397 controls were included in this study. Gene methylation in peripheral blood leukocytes was detected by a methylation-sensitive high-resolution melting method, and the Helicobacter pylori antibody presence was semi-quantified in serum by ELISA. Individuals with total methylation of CDKN2B/P15 had a 1.883-fold (95