Optogenetic termination of atrial tachyarrhythmias by brief pulsed light stimulation.

Motoki Nakao,Masaya Watanabe,Lucile Miquerol,Hiroyuki Natsui,Takuya Koizumi,Takahide Kadosaka,Taro Koya,Hikaru Hagiwara,Rui Kamada,Taro Temma,Antoine A F de Vries,Toshihisa Anzai

Journal of molecular and cellular cardiology（2023）

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摘要

Our results directly demonstrate that cationic channelrhodopsin activation by brief pulsed light stimulation prolongs the atrial refractory period suggesting that this is one of the key mechanisms of optogenetic termination of AT.

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关键词

Action potential,Atrial tachyarrhythmia,Channelrhodopsin-2,Optogenetic termination

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